Expression of Concern
This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 8, Issue 10 pp 2509—2524
MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway
Figure 9. miR-346 directly targeting XPC and then activating ERK/Snail pathway, which leads to decrease of E-cadherin. (A-B) Expression of XPC, phospho-ERK1/2, ERK2, Snail, and E-cadherin were detected in A549 and spc-a-1 cells either transiently transfected with NC, miR-346, si-XPC, or ASO-346. The intensity of XPC, phospho-ERK1/2, ERK2, Snail, and E-cadherin bands were quantified using Image J. Assays were performed in triplicate. *P < 0.05. Means ± SEM was shown. Statistical analysis was conducted using ANOVA.