Research Paper Volume 8, Issue 11 pp 2936—2947

Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells


Figure 1. Ubiquitin-dependent proteasome protein degradation pathway shown as an interacting network. Pathway activation features are shown for the averaged pediatric ALL, pediatric AML and adult AML transcriptomes. Up-regulated nodes are shown in green, down-regulated - in purple, color legend is provided at the bottom. Saturation of the color is proportional to logarithm of cancer-to-normal (CNR) expression rate for each node of the pathway.