Research Paper Volume 9, Issue 1 pp 156—172

Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice

Figure 1. The effect of Salvia miltiorrhiza bunge (SM) on the estrous cycle. ICI refers to the estrogen antagonist ICI182, 780 and E2 to 17β -estradiol. (A) The estrous cycle of the Immature mice, (i) the control group with untreated; (ii) Treated with estradiol (E2) ; (iii) Treated with Salvia miltiorrhiza bunge (SM) and (iV) Treated with Salvia miltiorrhiza bunge (SM) with estrogen receptor antagonist (ICI182, 780). (B) The estrous cycle of the OVX mice, (i) Ovariectomized (OVX) mice untreated; (ii) Sham group with untreated; (iii) Treated with Salvia miltiorrhiza bunge (SM) and (iV) Treated with Salvia miltiorrhiza bunge (SM) with estrogen receptor antagonist (ICI182, 780).