Research Paper Volume 9, Issue 1 pp 156—172

Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice

Figure 2. The effects of SM on uterine, body weights and adrenal gland. (A) The uterine weights of immature mice were measured at the end of the 7-day treatment period. (B) The uterus index for ovariectomized (OVX) mice was measured at the end of the 4-week treatment period. (C) Body weights of OVX mice were measured once per week for 4 weeks. (D) The adrenal gland index of ovariectomized (OVX) mice was measured at the end of the 4-week treatment period. Data are the mean and standard deviation (SD) of samples from 10 mice. P values are for the one-way analysis of variance (ANOVA) comparing the treatment group with untreated mice. (A) ***P < 0.001, **P < 0.01 and *P < 0.05 compared with the Con group; ###P < 0.001 compared with the SM group or E2 group; (B, C, D) ***P < 0.001 and *P < 0.05 compared with the Sham group; ###P < 0.001 and #P < 0.05 compared with the OVX group;∆∆∆P < 0.001, ∆∆P < 0.01, and P < 0.05 compared with the SM group or E2 group.