Research Paper Volume 9, Issue 1 pp 156—172

Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice

Figure 3. The effects of SM on serum estradiol (E2), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in immature and ovariectomized (OVX) mice. (A) Serum levels of E2, LH and FSH from immature mice and (B) serum levels of E2, LH and FSH from ovariectomized (OVX) mice were measured at the end of the treatment period. Data are the mean and standard deviation (SD) of samples from 10 mice. P values are for the one-way analysis of variance (ANOVA) comparing treatment groups with untreated mice. (A) ***P < 0.001, **P < 0.01 and *P < 0.05 compared with the Con group; ###P < 0.001; ##P < 0.01 and #P < 0.05 compared with the SM group or E2 group; (B) ***P < 0.001; **P < 0.01 and *P < 0.05 compared with the Sham group; ###P < 0.001 and ##P < 0.01 compared with the OVX group;∆∆∆P < 0.001, ∆∆P < 0.01, and P < 0.05 compared with the SM group or E2 group.