Research Paper Volume 9, Issue 1 pp 156—172

Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice

Figure 4. The effects of SM on the histology of the uterus and vagina in immature and ovariectomized (OVX) mice. Representative photomicrographs taken at 200-X magnifiation of uterine in immature mice; 100-X magnifiation of uterine in ovariectomized (OVX) mice and 400-X magnifiation of vaginal sections. (A, B) are the histology of the uterus and vagina in immature mice. (C, D) are the histology of the uterus and vagina in ovariectomized (OVX) mice. The treatment groups in immature mice are shown: (i) control group; (ii) treated with E2; (iii) treated with E2 and ICI; (iv) treated with SM at 1.6 g/kg; (v) treated with SM at 1.6 g/kg and ICI, (vi) treated with SM at 3.2 g/kg; (vii) treated with SM at 3.2 g/kg and ICI. The treatment groups in OVX mice are shown: (i) sham-operated mice; (ii) untreated OVX mice; (iii) treated with E2; (iv) treated with E2 and ICI, (v) treated with SM at 1.6 g/kg; (vi) treated with SM at 1.6 g/kg and ICI; (vii) treated with SM at 3.2 g/kg; (viii) treated with SM at 3.2 g/kg and ICI.