Research Paper Volume 8, Issue 12 pp 3535—3551

Figure 8. Effect of TORINs on senescent morphology of MEL10 cells undergoing senescence by treatment with nutlin 3a. Cells were treated with nutlin 3a (2.5 µM) and TORINs at selected concentrations or rapamycin (R). After 4-day treatment drugs were washed out and cells were incubated in drug-free medium for another 2 days and stained for SA-beta-gal. Bar – 100 µm. Nut – nutlin 3a; AZD – AZD8085.