Research Paper Volume 9, Issue 2 pp 583—599

Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging

Figure 1. Accumulation of p62 and ubiquitinated proteins in old skeletal and cardiac muscle. (A-B) Immunoblot and densitometric analysis of LC3B and p62 in young and old skeletal muscle (A) and heart (B). (C-D) mRNA expression of LC3B, p62 in young and old skeletal muscle (C) and heart (D). (E-F) Immunoblot and densitometric analysis of ubiquitinated proteins in young and old skeletal muscle (E) and heart (F). Values are means±SEM for 6 young and 5 old mice in each group. *P < 0.05, **P < 0.01.