Research Paper Volume 9, Issue 3 pp 706—740

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption

Figure 6. Functional signaling transposition between the GIT2KO thymus and PTLs. Signaling analysis of transcripts differentially and significantly regulated between GIT2KO and WT thymus (A). The top 10 pathways containing the most downregulated transcripts are indicated. Upregulated (red) or downregulated (green) transcripts populating these specific pathways are indicated in the histogram. Signaling analysis of transcripts differentially and significantly regulated between the PTL and the GIT2KO thymus (B). Venn diagram comparison of the functional cross-over between GIT2KO thymus pathways containing the greatest number of downregulated transcripts (>5%) with the GIT2 PTL pathways containing the greatest number of upregulated transcripts (>5%) (C). Histograms indicate the functional transcript expression nature of the 25 shared signaling pathways (from C) common between the GIT2KO thymus and the PTLs (D).