Research Paper Volume 9, Issue 3 pp 914—931

Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer

Figure 2. Rab1B and MMP9 expressions are significantly increased in colorectal cancer tissues. (A) Shown are representative immunohistochemistry (IHC) staining of Rab1B and MMP9 in CRC and adjacent non-tumor tissues. Scale bars represent 50 μm. (B) Comparison of Rab1B protein expressions between CRC tissues and matched adjacent non-tumorous tissues. (C) Comparison of MMP9 protein expressions between CRC tissues and matched adjacent non-tumorous tissues. (D) The expression levels of Rab1B and MMP9 proteins in eight pairs of CRC tissues (T) and adjacent non-tumorous tissues (N) are analyzed by immunoblot. (E) Concordance of Rab1B and MMP9 expressions in CRC. Consecutive CRC sections were analyzed for the expression of Rab1B and MMP9 by IHC. Shown are two representative cases. Scale bars represent 50 μm. (F) The correlation between Rab1B and MMP9 protein expressions in CRC tissues as evaluated by Spearman correlation analysis.