Research Paper Volume 9, Issue 3 pp 964—985

APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer’s Disease

Figure 3. Effect of fish oil/omega-3 supplement use on the AA and DHA containing species within blood PL classes. Mean ± SE(17 ε4- controls and 5 ε4 controls) for subjects who reported yes for using fish oil/omega-3 supplement. (A) Relative to non-users, ratios of AA to DHA were decreased in several PL classes in both ε4- and ε4+ controls who reported using fish-oil/omega-3 supplements. (B) Individual AA species (ePC(36:4), ePC(38:4), PC(36:4), LPC(20:4)) were generally decreased whereas DHA containing species (PC(40:6), PC(40:7), ePE(40:6), PE(40:6), and PI(40:6) were increased in several PL classes in both ε4- and ε4+ controls who reported using fish-oil/omega-3 supplements. While LPC(22:6) was increased in supplement users with ε4- genotype, levels of this lipid did not change in ε4+ individuals. *p < 0.05 for post-hoc analyses.