Research Paper Volume 10, Issue 1 pp 34—55

Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice

Figure 1. Sarcopenia symptoms begin at early stages of life in mice. Each bar represents mean ± SD of 6-8 mice per group. *p<0.05. **p<0.01 ***p<0.001. (A) Body Weight reached a maximum peak in the 10-14 months old group. (B) Muscle Weight increased significantly in the 6-9 months old group. (C) Epididymal Adipose Tissue Weight increased significantly in the three adult groups when compared with juvenile mice. (D) Resistance was determined by the time mice kept running at an 80% of maximal speed reached by each animal and was significantly decreased in the older groups (E) Impulse (N*s) was determined by Grip assay and is significantly decreased in the Older group (F) Maximal Speed significantly decreased in the older groups.