**Figure 2.** **Volcano plot of differentially-expressed circRNAs** (**A**), miRNAs (**B**), and mRNAs (**C**) between AD and sham hippocampal samples. Volcano plots were constructed using fold-change values and *p*-values. The vertical lines correspond to 2.0-fold up- and down-regulation between normal and AD samples (N *vs.***D**), and the horizontal lines represent *p*-values. Red plot points represent differentially-expressed circRNAs with statistical significance.