Research Paper Volume 10, Issue 5 pp 902—929

Testosterone and dihydrotestosterone reduce platelet activation and reactivity in older men and women

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Figure 1. Testosterone affects platelet aggregation induced by arachidonate or collagen in blood taken from men and from women. Data is presented as medians (thick horizontal lines) and interquartile ranges (IQR) (boxes, from lower quartile [25%] to upper quartile [75%]). Raw data is presented as black solid triangles or grey solid circles (outliers, by two-sided Tukey’s test: 1.5*[IQR]) for whole blood platelets stimulated with either arachidonate (0.5 mmol/l) (A, C) or collagen (1 µg/ml) (B, D) in men (A, B) and women (C, D). For experimental details, see Materials and methods. The significance of differences was estimated for Box-Cox-transformed data by the bootstrap-boosted (10000 iterations) ANOVA for repeated measures and the paired Student’s t-test with Bonferroni’s correction for post hoc multiple comparisons: P < 0.0005, µ0 ≠ µ0.1 = µ0.5 = µ1 = µ2.5 = µ5 = µ10 for arachidonate-activated platelets in men; P < 0.001, µ0 ≠ µ0.1 = µ0.5 = µ1 = µ2.5 = µ5 = µ10 for collagen-activated platelets in men; P < 0.001, µ0 ≠ µ0.1 = µ0.5 = µ1 = µ2.5 = µ5 = µ10 for arachidonate-activated platelets in women; P < 0.05, µ0 ≠ µ0.1 = µ0.5 = µ1 = µ2.5 = µ5 = µ10 for collagen-activated platelets in women.