Research Paper Volume 10, Issue 5 pp 902—929

Testosterone and dihydrotestosterone reduce platelet activation and reactivity in older men and women

Figure 3. Oestradiol affects platelet aggregation induced by arachidonate or collagen in male and female blood. Data s presented as medians (thick horizontal lines) and interquartile ranges (IQR) (boxes, from lower quartile [25%] to upper quartile [75%]). Raw data is presented as black solid triangles or grey solid circles (outliers, by two-sided Tukey’s test: 1.5*[IQR]) for whole blood platelets stimulated with either arachidonate (0.5 mmol/l) (A, C) or collagen (1 µg/ml) (B, D) in men (A, B) and women (C, D). For experimental details, see Materials and methods. The significance of differences is estimated for Box-Cox-transformed data by the bootstrap-boosted (10000 iterations) ANOVA for repeated measures and the paired Student’s t-test with Bonferroni’s correction for post hoc multiple comparisons: P < 0.01, µ0 ≠ µ0.01 = µ0.1 = µ0.3 for arachidonate-activated platelets in men; P < 0.01, µ0 ≠ µ0.1 = µ0.3 for collagen-activated platelets in men; P < 0.01, µ0 ≠ µ0.1 = µ0.3 for arachidonate-activated platelets in women; P < 0.05, µ0 ≠ µ0.01 = µ0.1 = µ0.3 for collagen-activated platelets in women.