Figure 3. Oestradiol affects platelet aggregation induced by arachidonate or collagen in male and female blood. Data s presented as medians (thick horizontal lines) and interquartile ranges (IQR) (boxes, from lower quartile [25%] to upper quartile [75%]). Raw data is presented as black solid triangles or grey solid circles (outliers, by two-sided Tukey’s test: 1.5*[IQR]) for whole blood platelets stimulated with either arachidonate (0.5 mmol/l) (A, C) or collagen (1 µg/ml) (B, D) in men (A, B) and women (C, D). For experimental details, see Materials and methods. The significance of differences is estimated for Box-Cox-transformed data by the bootstrap-boosted (10000 iterations) ANOVA for repeated measures and the paired Student’s t-test with Bonferroni’s correction for post hoc multiple comparisons: P < 0.01, µ0 ≠ µ0.01 = µ0.1 = µ0.3 for arachidonate-activated platelets in men; P < 0.01, µ0 ≠ µ0.1 = µ0.3 for collagen-activated platelets in men; P < 0.01, µ0 ≠ µ0.1 = µ0.3 for arachidonate-activated platelets in women; P < 0.05, µ0 ≠ µ0.01 = µ0.1 = µ0.3 for collagen-activated platelets in women.