Research Paper Volume 10, Issue 8 pp 2037—2050

The long non-coding RNA FLJ46906 binds to the transcription factors NF-κB and AP-1 and regulates expression of aging-associated genes

Figure 3. Aging-associated genes are regulated by the lncRNA FLJ46906. (A) Baseline expression of IL1B (interleukin-1β), IL6 (interleukin-6), CXCL8 (interleukin-8), TGFB (transforming growth factor-b), and ELN (elastin), as determined by qPCR, is altered by knockdown of FLJ46906 (n = 3, mean ± SD, *p < 0.05, **p < 0.01). (B) The induction of IL-6 by TNF-α (20 ng/ml; R&D Systems) is partially inhibited by knockdown of FLJ46906 (n = 3, mean ± SD, **p < 0.01).