A <i>Drosophila</i> model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention

Ruben Prange; Marcus Thiedmann; Anita Bhandari; Neha Mishra; Anupam Sinha; Robert Häsler; Philipp Rosenstiel; Karin Uliczka; Christina Wagner; Ali Önder Yildirim; Christine Fink; Thomas Roeder

doi:doi:10.18632/aging.101536

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Research Paper Volume 10, Issue 8 pp 2122—2135

A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention

Figure 1. CS exposure alters physiological parameters. (A) Lifespan of chronically CS exposed w¹¹¹⁸ female flies (red symbols) compared to that of matching controls (black symbols). Statistical analysis revealed signficant differences (p< 0.0001, n =8). (B) Body fat contents of 10d CS exposed w¹¹¹⁸ females (red) and of matching controls (black). Mean values are significantly different (p<0.0001, n=5). (C) Mean metabolic rate of w¹¹¹⁸ females after 10d of CS exposure and their matching controls (p<0.005, n = 11). Red symbols/bars mean CS exposed, black symbols/bars mean matching controls.