Research Paper Volume 10, Issue 9 pp 2394—2406

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Figure 1. Rolipram improves adipose distribution in presenile mice. (A) Masson’s trichrome staining of the skin of mice with or without rolipram treatment. The blue staining shows the collagen content (original magnification: 10x in both images). (B-D) Hematoxylin and eosin staining of the skin (B), kidney adipose (C) and liver tissue (D) in mice with or without rolipram treatment. The unstained vacuoles are the adipose tissue (original magnification: 40x in both images).