Research Paper Volume 10, Issue 9 pp 2394—2406

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Figure 5. Rolipram increases levels of SIRT6. (A) Western blots results for SIRT1, SIRT3, SIRT6 and acetylated NF-κB in the livers and kidneys of presenile mice. (B) Western blot results for SIRT1, SIRT3, SIRT6 and acetylated NF-κB in the livers and kidneys of presenile mice, with or without rolipram treatment.