Research Paper Volume 10, Issue 9 pp 2394—2406

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Figure 6. Roliparm decreases levels of acetylated NF-κB. (A) SIRT6 protein and NF−κB acetylation level of HFD-fed mice with or without db-cAMP treatment. (B) SIRT6 and acetylated NF-κB levels in Sirt6 knockdown and control cells, with or without db-cAMP treatment.