Research Paper Volume 10, Issue 10 pp 2585—2605

H3K9me3 and H4K20me3 represent the epigenetic landscape for 53BP1 binding to DNA lesions

Figure 10. Schematic illustration of a nucleosome with DSB occupied by studied proteins of interest in G1 and late S phase of the cell cycle. (A) Schema of an intact nucleosome. (B) Nucleosome with wound DNA with DSB. (C) A pictorial illustration of histone signature and recruitment of the 53BP1 protein to DNA lesions in the G1 phase of the cell cycle. Immunoprecipitation result shows dimerization of 53BP1 protein. (D) An illustration of histone signature and recruitment of PCNA and BRCA1 proteins to DNA lesions in late S phase of the cell cycle. Panels represent a schematic illustration of the results.