Research Paper Volume 10, Issue 10 pp 2783—2799

Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition

Figure 1. USP4 expression was significantly upregulated in HCC. (A) USP4 expression in HCC tumor tissues and matched surrounding tissues were examined by immunohistochemical staining. (magnification, ×40 and ×200). (B) Immunohistochemical scores of USP4 expression in HCC tumor tissues and matched surrounding tissues (** P < 0.01). (C) The mRNA level of USP4 in normal liver tissues and HCC tumor tissues which were collected from Oncomine data base (** P < 0.01). (D) USP4 expression in fresh HCC tumor tissues and matched surrounding tissue were examined by western blotting (N, matched surrounding tissues, T, tumor tissues).