Research Paper Volume 10, Issue 10 pp 2783—2799

Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition

Figure 2. High expression of USP4 was positive associated with HCC poor survival and some pathological characteristics. (A) Kaplan–Meier survival curve showed the correlation between USP4 expression in tumor tissues and survival of patients with HCC, (P=0.032), 1: low USP4 expression, 2: high USP4 expression. (B) Kaplan–Meier survival curve shows the correlation between USP4 expression in matched surrounding tissues and survival of patients with HCC, (P=0.708), 1: low USP4 expression, 2: high USP4 expression. (C) USP4, Ki67 and CD34 expression were tested by immunohistochemical staining in HCC tissues (magnification, ×200). (D) USP4 expression was positively correlated with the expression of Ki67(p=0.001, r=0.333). (E) USP4 expression was positively correlated with the expression of CD34 (p=0.008, r=0.269).