Research Paper Volume 10, Issue 10 pp 2783—2799

Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition

Figure 7. USP4 expression was positively correlated with EMT process in HCC tumor tissues. (A) Immunohistochemical staining (IHC) detected the expression of USP4, TGFR-1, E-cadherin, N-cadherin in USP4 low expression cases (magnification, ×400). (B) Immunohistochemical staining (IHC) detected the expression of USP4, TGFR-1, E-cadherin, N-cadherin in USP4 high expression cases (magnification, ×400). (C) The correlation between USP4 expression and TGFR-1, E-cadherin, N-cadherin was analyzed by Spearman rank correlation. r>0 and p < 0.05 was considered positive associated, r<0 and p < 0.05 was considered negative associated.