Research Paper Volume 10, Issue 10 pp 2832—2854

A multi-tissue full lifespan epigenetic clock for mice

Figure 5. Genome-wide association results for DNAm Age. (a) Manhattan plot presenting genome-wide association results for DNAm Age. Epigenetic age predictions were calculated using all CpGs clock with ridge regression and leave-one-sample-out estimates. GWAS analysis was based on linear mixed model and a set of 196,148 SNPs (MAF > 0.05) from HMDP mice strains. (b) This SNP as identified using GWAS analysis of epigenetic age predictions. It is located in an LD block on chromosome 6 and contains the genes Npy, Mpp6, Gsdme and Osbp13. A one-sided t-test of DNAm ages between the two allelic groups shown is statistically significant. (c) It is located in an LD block on chromosome 6 and contains the genes Npy, Mpp6, Gsdme and Osbp13. A one-sided t-test of DNAm ages between the two allelic groups shown is statistically significant.