Review Volume 10, Issue 11 pp 3590—3609

The senescent cell epigenome

Figure 1. Histone modification changes in senescence. Senescence is associated with an imbalance of histone modifications with a tendency towards accumulating euchromatin marks. Additional features include formation of new super-enhancers near SASP genes in OIS, H3K27me3 “canyons” where SASP genes reside, H3K4me3 “mesas”, and formation of SAHFs.