Review Volume 10, Issue 11 pp 3590—3609

The senescent cell epigenome

Figure 5. A visual summary of current senotherapies. Aged tissues tend to accumulate senescent cells which impose detrimental changes to tissue structure, regenerative ability and physiological function due to chronic inflammation. Current and plausible strategies to treat these adverse effects include administration of senolytics, rejuvenation therapy by induce partial reprogramming to a “youthful” state, anti-SASP therapy to prevent the generation and release of inflammatory cytokines and immunotherapy to activate innate immune mechanisms of the body, which in turn, clear senescent cells naturally.