Figure 4. Senescence-associated gene expression profile in senescent and young RPESCs. PCR array performed to analyze the mRNA expression levels of senescence-associated genes in 3 senescent (P16) and 3 young (P3) RPESCs. Data are reported as fold change. A 4-fold difference was considered significant and only mRNAs with a ΔΔCt greater than 4 (A) or lower than -4 (B) are reported. *P = from 0.018 to 0.046.