Research Paper Volume 10, Issue 12 pp 3662—3682

Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203

Figure 5. miR-203 expression pattern in colon cancer. (A) miR-203expression in 64 pairs of primary colon cancer tissues and adjacent colonic epithelium tissues was measured by qRT-PCR. P < 0.0001, Wilcoxon signed-rank test. (B) The correlation between B3GALT5-AS1 and miR-203 expression level in colon cancer tissues. n = 64, r = -0.7625, P < 0.0001, Pearson’s correlation analysis. (C) The expression of miR-203 in 15 pairs of primary colon cancer tissues and corresponding liver metastasis tissues was measured using qRT-PCR. P < 0.0001, Wilcoxon signed-rank test. (D) The expression of ZEB2 in 15 pairs of primary colon cancer tissues and corresponding liver metastasis tissues was measured using qRT-PCR. P = 0.0006, Wilcoxon signed-rank test. (E) The expression of SNAI2 in 15 pairs of primary colon cancer tissues and corresponding liver metastasis tissues was measured using qRT-PCR. P = 0.0034, Wilcoxon signed-rank test. (F) The expression of E-cadherin in 15 pairs of primary colon cancer tissues and corresponding liver metastasis tissues was measured using qRT-PCR. P < 0.0001, Wilcoxon signed-rank test. (G) The expression of N-cadherin in 15 pairs of primary colon cancer tissues and corresponding liver metastasis tissues was measured using qRT-PCR. P = 0.0002, Wilcoxon signed-rank test.