Research Paper Volume 10, Issue 11 pp 3308—3326

ZNF185 is a p53 target gene following DNA damage

Figure 5. ZNF185 is down-regulated in skin cancer. (A) Immunohistochemical analysis of ZNF185 expression in normal skin. Ki67 was used as a marker of proliferation. Scale bar: 100 µm. (B) Immunohistochemical analysis of ZNF185 expression in skin cancer: cutaneous basal cell (cBCC), squamous cell carcinoma (cSCC), and malignant melanoma (cMM). Ki67 was used as a marker of proliferation. Scale bar: 250 µm. (C) Immunohistochemical analysis of ZNF185 expression in cutaneous squamous cell carcinoma (well differentiated). Ki67 was used as a marker of proliferation. Scale bar: 50 µm. (D) Violin plot showing H-score of protein expression level of ZNF185 in the normal skin (D – dermis, SB – basal layer, SS/SG – spinous and granular layers, SC – cornified layer) and skin cancer (cSCC (cSCC subpopulations: PD – poorly-differentiated cells, WD – well-differentiated cells), cBCC, and cMM).