Research Paper Volume 10, Issue 11 pp 3353—3370

LOC134466 methylation promotes oncogenesis of endometrial carcinoma through LOC134466/hsa-miR-196a-5p/TAC1 axis

Figure 11. LOC134466/hsa-miR-196a-5p/TAC1 axis affected EC carcinogenesis through neuroactive ligand-receptor interaction. (A-B) The effects of LOC134466 or TAC1 overexpression on TACR1, TACR2 and TACR3 expression were determined by western blot. Protein expression was normalized to that of GADPH. (C) The TAC1 network was generated by Stich website. The neuroactive ligand-receptor interaction was marked red. (D) A model of LOC134466/hsa-miR-196a-5p/TAC1 axis action on EC development. ** P<0.01 compared with corresponding control group.