Figure 1. Comparative transcriptomics in giant mole-rats and laboratory rats of elderly vs. young individuals. (A) Counts of differentially expressed genes (DEGs) during aging in five tissue types from laboratory rats (Rattus norvegicus) and giant mole-rat (Fukomys mechowii). Only orthologous genes in both transcript catalogs were counted (n=14,062). (B) Numbers of biological processes (Gene Ontology) enriched for DEGs during aging in five tissue types from laboratory rats (R. norvegicus) and giant mole-rats (F. mechowii).