Research Paper Volume 11, Issue 2 pp 590—614

Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism

Figure 10. RT-PCR detection of the relative expression of TERT, TCAB1, P21, SIRT1 and SIRT6 in BMSCs. The results showed that TERT, SIRT1 and SIRT6 expression levels were significantly lower in the aged cell group than in the juvenile cell group (P < 0.01). P21 expression was significantly increased (P < 0.01), and TCAB1 expression was significantly decreased (P < 0.05). Compared with those in the juvenile cell group, TERT and SIRT6 levels were significantly decreased (P < 0.01) and P21 levels were significantly increased (P < 0.01) in the induced senescence group. TERT expression was significantly decreased in the induced aging group compared with the aged cell group (P < 0.01), and SIRT6 expression was significantly decreased (P < 0.05).