Research Paper Volume 11, Issue 3 pp 950—973

Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time

Figure 3. Input pathways to the oscillator of circadian clocks are comparable between the proliferative and senescent cells. (A) Oscillation patterns of luciferase synchronized by dexamethasone (Dex) or forskolin (Fsk) were monitored by using a real-time luciferase monitoring system. Three independent experiments were performed. (B) Summary of peak-times and the difference of peak-time in the proliferative and senescent cells shown in (A). Statistical analyses were performed by Student’s two-tailed t test, n=8.