Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time

Rezwana Ahmed; Atsushige Ashimori; Satoshi Iwamoto; Takaaki Matsui; Yasukazu Nakahata; Yasumasa Bessho

doi:doi:10.18632/aging.101794

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Research Paper Volume 11, Issue 3 pp 950—973

Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time

Figure 7. Acute and circadian profiles of endogenous circadian genes were altered in the senescent cells. Acute responses of PER1 (A) and PER2 (B), and circadian profiles of PER2 (C) and BMAL1 (D) induced by Dex were quantified. Each sample was normalized by 18S rRNA. Time 0 of proliferative cells were set to 1 for each gene.