Figure 1. Development of a predictive miRNA signature for breast cancer risk among high-risk women. The predictive ability of A) the 6-miRNA risk signature and B) each individual C-miRNA was assessed by ROC curve and AUC based on calculated risk score. The combined expression of the 6 C-miRNAs discriminate cases from controls with increased accuracy and precision than any single miRNA. 95% confidence intervals (CI) are indicated by gray area around each curve. Modified from our 2017 Oncotarget publication .