Figure 2. Skin aging histological features compare earlier and more pronounced in CRABP-IIknock-out mice. (A) Representative Haematoxylin&Eosin and Masson's trichrome-stained skin sections of young/adult and old wild-type (WT) and CRABP-II knock-out (KO) mice. (B) Bar graphs show semiquantitative evaluation of skin aging parameters (n=10 young/adult and n=10 old WT, n=10 young/adult and n=10 old CRABP-II KO). Scale bar: 100µm. Values are group mean ± SEM. t-Test: *, ** and *** indicate p<0.05, p <0.01 and p< 0.001, respectively.