Research Paper Volume 11, Issue 6 pp 1619—1632

Cellular retinoic acid binding protein-II expression and its potential role in skin aging

Figure 6. Proliferation rate and transcriptional profiling are altered in cultured dermal fibroblasts from CRABP-IIknock-out mice. (A) Growth curve of cultured dermal fibroblasts from young/adult wild-type (WT, n=3) and CRABP-II knock-out mice (KO, n=3). (B) Col1A1, Col1A2, MMP2, TGFβ1, TGFβ RI and TGFβ RII mRNA normalized expression in dermal fibroblasts from young/adult WT and CRABP-II KO. Values are group mean ± SEM. t-Test: * and ** indicate p< 0.05 and p< 0.01, respectively.