Research Paper Volume 11, Issue 6 pp 1791—1803

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Figure 2. miR-34a is increased with age in muscle-derived, alpha-sarcoglycan positive (SGCA+) EVs. (A) Representative particle distribution histograms from nanoparticle tracking analysis showing similar particle sizes between serum EVs and SGCA+ serum EVs. (B) Particle concentrations of SGCA+ EVs are significantly lower than total serum EVs, and SGCA+ EVs in bone marrow are significantly less abundant than SGCA+ EVs in serum. (C) SGCA+ EVs show a significant increase in miR-34a expression with age.