Figure 3. White LED light activates GSK3 and nuclear receptor GR, RORα in HT-22 cells. (A–B) Protein content of total and phospho-GSK-3α/β (Ser21/9). Significant decrease of p-GSK3/GSK3 ratio in Light group indicates activation of both GSK3α and GSK3β; (C) Protein content of GR, phospho-GR, RORα and REV-ERBα, showing up-regulation of both GR and RORα in Light group; (D) Protein content of SIRT1, AMPK and phospho-AMPK. Values are means ± SEM. **p < 0.01, compared with Dark group (n = 6).