The cross-sectional associations between ARHL and CSF biomarkers. No association was found between ARHL and CSF Aβ42 levels (A). ARHL was associated with higher levels of CSF total tau (B) and ptau181 (C). All the above analyses were adjusted for age, gender, education, APOE4 status, pathological diagnosis of AD, DM2, hypertension, hyperlipidemia, BMI, and extracted CSF volume. *p value was calculated for the total sample.