Figure 3. The relationship between ARHL and hippocampus volume. ARHL was associated with larger volume of hippocampus. Nonetheless, when stratified by AD continuum stage, no association was found in any group. (A) ARHL was associated with more rapid cortical thinning, especially in the preclinical or prodromal AD stage (B). All analyses were adjusted for age, gender, education, APOE4 status, pathological diagnosis of AD (for total sample), DM2, hypertension, hyperlipidemia, BMI, and ICV. *p value was calculated for the total sample.