Research Paper Volume 11, Issue 10 pp 3156—3169

Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study

Figure 6. Flow chart of searching for ARHL. Abbreviations: HL = hearing loss; ARHL = age-related HL; CSF = cerebrospinal fluid, ROI = regions of interest. Searching terms for covariates: Hypertension: “hypert”, “HTN”, and “blood pressure”; Hyperlipemia: “lipid”, “cholesterol”, “hyperlipemia”, and “HLP”; DM2: “diabete”, “diabetic”, and “insulin”; Depression: “depress”. Other covariates (including age, gender, apoe4 status, education, diagnosis, and BMI) are accessible without searching the relevant database. *Other ROIs include middle temporal cortex, entorhinal cortex, parahippocampal area, posterior cingulate, and precuneus.