Research Paper Volume 11, Issue 11 pp 3574—3584

TGF-β mediates aortic smooth muscle cell senescence in Marfan syndrome

Figure 6. Proposed mechanisms for TGF-β1-induced VSMC senescence. This study shows that TGF-β1 induces VSMC senescence through activation of ROS/NF-κB signaling, which leads to aortic aneurysm formation in MFS patients.