Research Paper Volume 11, Issue 12 pp 3993—4010

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Figure 1. The intermediate metabolites of the pyrimidine metabolism pathway extended the lifespan of C. elegans. (A) Schematic representation of the pyrimidine metabolism pathway. (BH) Lifespan of worms treated with 0.5 mM (B) β-aminoisobutyrate (red), (C) orotate (red), (D) thymine (red), (E) uridine (red), (F) cytidine (red), (G) thymidine (red), (H) uracil (red), and vehicle (gray) at 20 °C. The treatments were administered beginning on day 1 of adulthood. Lifespan was analyzed using the Kaplan-Meier test, and P values were calculated using the log-rank test; no significant difference was abbreviated as n.s. Data are representative of at least two independent experiments, and lifespan values are listed in Supplementary Table 1.