Research Paper Volume 11, Issue 12 pp 3993—4010

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

class="figure-viewer-img"

Figure 6. Intermediate metabolites in pyrimidine metabolism extended adult lifespan in a DAF-12-dependent manner. (AD) Lifespan of daf-12 (rh274) animals treated with 0.5 mM (A) β-aminoisobutyrate, (B) cytidine (red), (C) orotate (red), (D) uridine (red), and vehicle (black). The P value was calculated by the log-rank test. Replicates of these experiments and statistical details are summarized in Supplementary Table 1.