Figure 6. Intermediate metabolites in pyrimidine metabolism extended adult lifespan in a DAF-12-dependent manner. (A–D) Lifespan of daf-12 (rh274) animals treated with 0.5 mM (A) β-aminoisobutyrate, (B) cytidine (red), (C) orotate (red), (D) uridine (red), and vehicle (black). The P value was calculated by the log-rank test. Replicates of these experiments and statistical details are summarized in Supplementary Table 1.