Research Paper Volume 11, Issue 12 pp 3993—4010

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Figure 6. Intermediate metabolites in pyrimidine metabolism extended adult lifespan in a DAF-12-dependent manner. (AD) Lifespan of daf-12 (rh274) animals treated with 0.5 mM (A) β-aminoisobutyrate, (B) cytidine (red), (C) orotate (red), (D) uridine (red), and vehicle (black). The P value was calculated by the log-rank test. Replicates of these experiments and statistical details are summarized in Supplementary Table 1.