Figure 10. Gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) of hub genes in the TCGA-PRAD dataset. (A–D) Top 3 gene sets (according to GSEA enrichment score) enriched in the high-expression group of single hub genes. (A) LMNB1; (B) TK1; (C) ZWINT; (D) RACGAP1. (E–H) GSVA-derived clustering heatmaps of differentially expressed pathways for single hub genes. (E) LMNB1; (F) TK1; (G) ZWINT; (H) RACGAP1. Only signaling pathways with log(foldchange) > 0.2 are shown.