Research Paper Volume 11, Issue 13 pp 4736—4756

Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis

Figure 7. Validation of hub genes in the TCGA-PRAD dataset. (A) LMNB1, TK1, RACGAP1, and ZWINT gene expression differences between PCa and adjacent normal tissues. (B) Expression of LMNB1, TK1, RACGAP1, and ZWINT in PCa samples with different Gleason scores. (C) Expression of LMNB1, TK1, RACGAP1, and ZWINT in PCa samples with different T stages. (D) Expression of LMNB1, TK1, RACGAP1, and ZWINT in PCa samples with different N stages. (E) Association between LMNB1, TK1, RACGAP1, and ZWINT expression and disease-free survival time in the TCGA-PRAD dataset. The yellow line indicates samples with highly expressed genes (above best-separation value), and the green line designates the samples with lowly expressed genes (below best-separation value). T, Tumor; N, Node.