Figure 6. Decrease in NMDAR synaptic responses in young animals, under oxidizing conditions, depends on CaMKII activity. (A) Time course of normalized NMDAR-fEPSP slope following application of DTNB (0.5 mM, arrow) in the young animals. Each point represents the mean (±SEM), normalized to the baseline (dashed line), for slices in the control condition (open circles) or following pre-incubation with the CaMKII inhibitor, KN-62 (10 µM, filled circles). DTNB reduced NMDAR synaptic response. Pre-incubation with KN-62 blocked the decrease in the NMDAR response associated with DTNB application. (B) Quantification of the mean percent change in the NMDAR-fEPSP slope during the last 5 min of recording in the presence of vehicle control (open, n = 7/7 slices/animals) and KN-62 (, n = 7/7 slices/animals). Pound sign indicates a significant difference between the two groups. The waveforms represent examples of NMDAR-fEPSPs recorded during baseline (1) and 60 min following application of DTNB (2) in the control condition (left) and following pre-incubation in KN-62 (right).