Figure 2. RhoA expression level as an independent prognostic factor in HCC. The high expression level of RhoA suggests poor prognosis based on the TCGA training set (A), and the optimal cutoff point was calculated via the X-tile method (B). High RhoA expression levels were also unfavorable in two GEO validation sets (C, GSE10186; D, GSE54236). Univariate and multivariate Cox regression analyses of clinical indicators and RhoA levels related to prognosis: red bars represent prognostic factors, and blue bars represent nonprognostic factors (E).